Inflammatory response of the human tooth pulp tissue to dental caries
DOI:
https://doi.org/10.15649/2346075X.475Keywords:
Pulp tissue; Dental caries; InflammationAbstract
Introduction: Dental caries is a chronic infectious disease resulting
from the penetration of oral bacteria into tooth hard tissues.
Microorganisms subsequently trigger inflammatory responses
in the dental pulp and the stem cells provide a source of cells to
replace the damaged cells and facilitate repair. These events can
lead to pulp healing if the infection is not too severe and treated
in a short time. Remaining pulpal pathosis in severe form without
treatment induces permanent loss of normal tissue due to limited
repair capacities in response to large damage. The importance
of the depth of inflammation has been underestimated in pulpal
healing. The purpose of this study is to investigate the pulp tissue
response to dental caries and to find out the association of different
distributions of the inflammatory characteristics among a different
depth of dental caries. Materials and Methods: Pulp tissue samples
were collected from 118 extracted teeth from the Privet dental clinics
and dental health centers in Duhok government, from April/ 2016 to
August/ 2017 (16 months period). Each section prepared and stained
with hematoxylin and Eosin (H&E). Inflammatory infiltration, fibrosis, calcification, and necrosis were the main features that have been
examined histopathologically and assessed with the presence of dental
caries at a different depth. Results and Discussion: Inflammatory
features were identified in 88 of the samples examined. Inflammatory infiltration and fibrosis were the most frequent features among
the deep caries teeth compared to the shallow caries teeth. Single and
group of calcification were observed in 57 samples, most of them (48
samples) were in deep caries sections. Conclusion: the histopathological observations of pulp tissue in response to caries process provide
useful information for the clinical aspect and how to decide and select
the best strategy in the treatment of dental caries at a different depth
to preserve the pulp tissue vitality for a longer time, and strength of
the tooth hard tissue will maintain.
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