Comparacion de biomarcadores sericos en pacientes con osteartritis y artritis rematoidea

Autores/as

  • Almandlawi S G Assistant Professor, Biology Department, College of Science, University of Duhok, Iraq
  • Ahmed A S Professor, Medical Laboratory Technology Department, Alnoor University College, Nineva, Iraq

DOI:

https://doi.org/10.15649/2346075X.473

Palabras clave:

Osteoarthritis; Rheumatoid arthritis; Vitamin D; Parathyroid hormone; Type II collagen

Resumen

Introduction: This study aims to assess the status of serum vitamin D, parathyroid hormone, type II collagen, calcium, phosphate, albumin, and alkaline phosphatase in osteoarthritis and rheumatoid arthritis patients and to study their association with rheumatoid arthritis disease activity. Materials and Methods: This prospective cross-sectional study was conducted at the clinical analysis department, College of Pharmacy, Hawler Medical University in 2017. They study samples were collected at Rizgary Teaching Hospital
during the period September 2015 to January 2016. A total of (N=156) participants were included: (N=53) patients with rheumatoid arthritis (RA), (N=53) with osteoarthritis (OA), and (N=50) healthy controls. Enzyme Linked Immuno Sorbent Assay kits determined serum vitamin D, parathyroid hormone, and type II collagen; and serum albumin, calcium, phosphate and alkaline phosphatase, were determined by standard colorimetric methods. Results: and Discussion: Statistically significant higher levels of parathyroid hormone and type II collagen, with lower levels of Vitamin D, were found in the osteoarthritis group than the rheumatoid arthritis group and the healthy controls (P=0.007, P<0.001, P= 0.005) respectively. Multiple linear regression showed a statistically significant difference in serum type II collagen as a dependent variable, in
patients suffering from RA or OA compared to the healthy control group; after adjusting for the effect of other independent study variables, there was a mean increase of (45.90 nmol/L, P<0.001) in RA patients, and OA patients showed greater levels of type II collagen (73.950 nmol/L) than the health control group (P<0.001).
Conclusions: Elevated type II collagen levels, in conjunction with a low vitamin D status, may be strong discriminator between osteoarthritis and rheumatoid arthritis patients.

Biografía del autor/a

Almandlawi S G, Assistant Professor, Biology Department, College of Science, University of Duhok, Iraq

Assistant Professor, Biology Department, College of Science, University of Duhok, Iraq

Ahmed A S, Professor, Medical Laboratory Technology Department, Alnoor University College, Nineva, Iraq

Professor, Medical Laboratory Technology Department, Alnoor University College, Nineva, Iraq

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Publicado

2018-12-28

Cómo citar

S G, A., & A S, A. . (2018). Comparacion de biomarcadores sericos en pacientes con osteartritis y artritis rematoidea. Innovaciencia, 6(2), 1–11. https://doi.org/10.15649/2346075X.473

Número

Vol. 6 Núm. 2 (2018)

Sección

Artículo original de investigación e innovacion
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