Gravidez e infecção por Coronavírus: desfechos maternos, fetais e neonatais – Revisão sistemática
DOI:
https://doi.org/10.15649/cuidarte.1211Palabras clave:
Coronavirus, Complicaciones Infecciosas del Embarazo, Recién NacidoResumen
Introdução: Pouco se sabe sobre os efeitos da Síndrome Respiratória Aguda Grave do Coronavírus (SARS-CoV) durante a gravidez. O objetivo desse trabalho foi descrever os desfechos clínicos durante a gestação em mulheres que tiveram SARS-CoV-1 e SARS-CoV-2 e seu impacto na saúde fetal e do recém-nascido. Materiais e Métodos: Revisão sistemática realizada nas fontes de busca Periódicos Capes, Google Acadêmico, Lilacs e PubMed. Resultados: Foram selecionados 27 artigos científicos. A taxa de mortalidade foi maior em grávidas com SARS-CoV-1 do que SARS-CoV-2. Os sintomas mais relatados nas grávidas com o COVID-19 foram febre e tosse. A maioria dos estudos mostraram testagem negativa para SARS-CoV-1 e SARS-CoV-2 nos recém-nascidos de mães infectadas. Ambos os tipos de infecções causaram retardo do crescimento intrauterino e problemas respiratórios em neonatos. Discussão: As infecções por SARS-CoV-1 e SARS-CoV-2 compartilharam características clínicas comuns em gestantes, tais como, febre, tosse seca, dispneia, pneumonia e admissão em Unidade de Terapia Intensiva (UTI) para ventilação mecânica. Apesar de a literatura apontar a não transmissão vertical do coronavírus, foi encontrado níveis elevados de IgM em amostras de sangue de neonatos de mães que tiveram SARS-CoV-2 durante a gestação. Conclusões: Mais estudos precisam ser realizados para o melhor entendimento dos desfechos clínicos maternos, fetais e neonatais da SARS-CoV-2 durante a gestação, a fim de contribuir para tomada de decisões terapêuticas e de precaução da infecção
Como citar este artigo: Furlan, Mara Cristina Ribeiro; Jurado, Sonia Regina; Uliana, Catchia Hermes; Silva, Maria Eduarda Pascoaloto; Nagata, Letícia Akie; Maia, Anna Clara Freitas. Gravidez e infecção por coronavírus: desfechos maternos, fetais e neonatais – Revisão sistemática. Revista Cuidarte. 2020; 11(2): e1211. http://dx.doi.org/10.15649/cuidarte.1211
Referencias
Hui DS. Epidemic and emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). Clin Chest Med. 2017; 38(1): 71-86. https://doi.org/10.1016/j.ccm.2016.11.007
Li T. Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0). Emerg Microbes Infec. 2020; 9 (1). https://doi.org/10.1080/22221751.2020.1735265
Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020. https://doi.org/10.1016/j.ajogmf.2020.100107
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395: 809-15. https://doi.org/10.1016/S0140-6736(20)30360-3
Mardani M, Pourkaveh B. A Controversial Debate: Vertical Transmission of COVID-19 in Pregnancy. Arch Clin Infect Dis. 2020; 15(1): e102286. https://doi.org/10.5812/archcid.102286
Centers for Disease Control and Prevention. Frequently asked questions and answers: Coronavirus disease 2019 (COVID-19) and pregnancy. CDCP; 2020. https://www.cdc.gov/coronavirus/2019-ncov/faq.html
Qiao Y, Wang J, Li J, Wang J. Effects of depressive and anxiety symptoms during pregnancy on pregnant, obstetric and neonatal outcomes: a follow-up study. J Obstet Gynaecol. 2012; 32(3): 237-40. https://doi.org/10.3109/01443615.2011.647736
Alder J, Fink N, Bitzer J, Hosli I, Holzgreve W. Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern-Fetal Neo M. 2007; 20(3): 189-209. https://doi.org/10.1080/14767050701209560
Fakari RF, Simbar M. Coronavirus Pandemic and Worries during Pregnancy; a Letter to Editor. Arch Acad Emerg Med. 2020; 8(1): e21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075675/pdf/aaem-8-e21.pdf
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020; 395(10224): 565-74. https://doi.org/10.1016/S0140-6736(20)30251-8
Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12 (2): 194-210. https://doi.org/10.3390/v12020194
Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Latino-Am Enfermagem. 2007; 15(3): 508-11. https://doi.org/10.1590/S0104-11692007000300023
Moher D, Liberati A, Tetzlaff J, Altman DG. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiol Serv Saúde. 2015; 24(2): 335-42. https://doi.org/10.5123/S1679-49742015000200017
Chen R, Zhang Y, Huang L, Cheng B, Xia Z, Meng Q. Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Can J Anesth. 2020. https://doi.org/10.1007/s12630-020-01630-7
Chen Y, Peng H, Wang L, Zhao Y, Zeng L, Gao H, et al. Infants born to mothers with a new coronavirus (COVID-19). Front. Pediatr. 2020; 8: 104. https://doi.org/10.3389/fped.2020.00104
Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy, Journal of Infection (2020), doi: https://doi.org/10.1016/j.jinf.2020.02.028
Li N, Han L, Peng M, Lv Y, Ouyang Y, Lui K, et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. medRxiv. 2020. https://doi.org/10.1101/2020.03.10.20033605
Wang X, Zhou Z, Zhang J, Zhu F, Tang Y, Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa200
Chen S, Liao E, Cao Y, Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020. https://doi.org/10.1002/jmv.25789
Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China. Emerg Infect Dis. 2020; 26(6). https://doi.org/10.3201/eid2606.200287
Word Health Organization. Coronavirus disease 2019 (Covid-19) situation report 46. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_2
Liu H, Lui F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children, J Infect. 2020. https://doi.org/10.1016/j.jinf.2020.03.007
Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A Preliminary analysis. AJR. 2020; 215: 1-6. https://doi.org/10.1016/j.jinf.2020.03.007
Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G,et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020; 9(1): 51-60. https://doi.org/10.21037/tp.2020.02.06
Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet.2020; 20: 559-64 https://doi.org/10.1016/S1473-3099(20)30176-6
Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv. 2020. https://doi.org/10.1101/2020.01.30.927806
Zambrano LI, Fuentes-Barahona IC, Bejarano-Torres DA, Bustillo C, Gonzalez G, Vallecillo-Chinchilla G, et al. A Pregnant Woman with COVID-19 in Central America. Travel Med Infect Dis. 2020. https://doi.org/10.1016/j.tmaid.2020.101639
Lam CM, Wong SF, Leung TN, Chow KM, Yu WC, Wong TY, et al. A case-controlled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome. BJOG. 2004; 111 (8): 771-74. https://doi.org/10.1111/j.1471-0528.2004.00199.x
Wong SF, Chow KM, Leung TN, Lai ST, Yan WW, Tan PYH, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 2004; 191 (1): 292-97. https://doi.org/10.1016/j.ajog.2003.11.019
Shek CC, Ng PC, Fung GPG, Cheng FWT, Chan PKS, Peirirs MJS, et al. Infants born to mothers with severe acute respiratory syndrome. Pediatrics. 2003; 112(4): e254 https://doi.org/10.1542/peds.112.4.e254
Stockman LA, Lowther SA, Coy K, Saw J, Parashar UD. SARS during Pregnancy, United States. Emerg Infect Dis. 2004;10(9):1689-690. https://doi.org/10.3201/eid1009.040244
Dong Y, Mo X, Hu Y, Tong S. Epidemiological and transmission patterns of pregnant women with 2019 coronavirus disease in China. Lancet. 2020. https://doi.org/10.2139/ssrn.3551330
Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. Am J Obstet Gynecol. 2020. https://doi.org/10.1016/j.ajog.2020.02.017
Robertson CA, Lowther SA, Births T, Tan C, Sorhage F, Stockman L, et al. SARS and pregnancy: A Case report. Emerg Infect Dis. 2004; 10(2): 345-48. https://doi.org/10.3201/eid1002.030736
Liu W, Wang Q, Zhang Q, Chen L, Chen J, Zhang B, et al. Coronavirus Disease 2019 (COVID-19) During Pregnancy: A Case Series. Preprints 2020, 2020020373 https://www.preprints.org/manuscript/202002.0373/v1
Yue L, Han L, Li Q, Zhong M, Wang J, Wan Z, et al. Anaesthesia and infection control in cesarean section of pregnant women with coronavirus disease 2019 (COVID-19). medRxiv. 2020. https://doi.org/10.1101/2020.03.23.20040394
Fan C, Lei D, Fang C, Li C, Wang M, Liu Y, et al. Perinatal Transmission of COVID-19 associated SARS-CoV-2: Should we worry? Clini Infect Dis, 2020. https://doi.org/10.1093/cid/ciaa226
Lee DH, Lee J, Kim E, Woo K, Park HY, An J. Emergency cesarean section performed in a patient with confirmed severe acute respiratory syndrome Coronavirus-2: A case report. Korean J Anesthesiol. 2020. https://doi.org/10.4097/kja.20116
Khan, S., Peng, L., Siddique, R., Nabi, G., Nawsherwan, Xue, M., . . . Han, G. (2020). Impact of COVID-19 infection on pregnancy outcomes and the risk of maternal-to-neonatal intrapartum transmission of COVID-19 during natural birth. Infection Control & Hospital Epidemiology, 1-3. https://doi.org/10.1017/ice.2020.84
Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. https://doi.org/10.1001/jamapediatrics.2020.0878
Nie R, Wang S, Yang Q, Fan C, Liu Y, He W, et al. Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019. medRxiv. 2020. https://doi.org/10.1101/2020.03.22.20041061
Zeng H, Xu C, Fan J, Thang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020. https://doi.org/10.1001/jama.2020.4861
Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020. https://doi.org/10.1001/jama.2020.4621
Kochhar DM, Penner JD, Knudsen TB. Embryotoxic, teratogenic, and metabolic effects of ribavirin in mice. Toxicol Appl Pharmacol. 1980; 52(1): 99-112. https://doi.org/10.1016/0041-008X(80)90252-5
Publicado
Cómo citar
Número
Sección
Altmetrics
Descargas
Licencia
Journal Cuidarte, scientific publication of open access, is licensed under a Creative Commons Attribution (CC BY-NC), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Any other form of use such as reproduction, transformation, public communication or distribution, for profit, requires the prior authorization of the University of Santander UDES.
The names and e-mail addresses entered in the Journal Cuidarte will be used exclusively for the purposes stated by this magazine and will not be available for any other purpose or other person.
The articles published in the Journal Cuidarte represent the criteria of their authors and do not necessarily constitute the official opinion of the University of Santander UDES.
