A Systematic Review of Pregnancy and Coronavirus Infection: Maternal, Fetal and Neonatal Outcomes

Authors

DOI:

https://doi.org/10.15649/cuidarte.1211

Keywords:

Coronavirus, Pregnancy Complications, Infectious, Infant, Newborn

Abstract

Introduction: The effects of severe acute respiratory syndrome (SARS-CoV) during pregnancy are little known. This study aims to describe clinical outcomes in pregnant women with SARS-CoV1 and SARS-CoV2 and their impact on the health of the fetus and newborn. Materials and Methods: A systematic review was conducted using the CAPES Portal of E-Journals, Google Scholar, LILACS, and PubMed search engines. Results: 27 research articles were selected. The mortality rate was higher in pregnant women with SARS-CoV1 than those with SARS-CoV2. The most common symptoms reported by pregnant women with COVID-19 were fever and cough. Most SARS-CoV1 and SARS-Cov2 tests had negative results in infants born to mothers with confirmed COVID-19. Both types of infections caused intrauterine growth restriction and breathing problems in newborns. Discussion: SARS-CoV-1 and SARS-CoV-2 infections share common clinical features such as fever, dry cough, dyspnea, pneumonia, and admission to intensive care unit (ICU) for mechanical ventilation. Although vertical transmission of coronavirus disease 19 is not reported in the literature, IgM levels were found in blood tests from infants of mothers who had SARS-CoV-2 during pregnancy. Conclusions: Further research is needed to better understand maternal, fetal, and neonatal clinical outcomes of SARS-CoV-2 during pregnancy to contribute to the precautionary principle and therapeutic decisions on this infection

How to cite this article: Furlan, Mara Cristina Ribeiro; Jurado, Sonia Regina; Uliana, Catchia Hermes; Silva, Maria Eduarda Pascoaloto; Nagata, Letícia Akie; Maia, Anna Clara Freitas. Gravidez e infecção por coronavírus: desfechos maternos, fetais e neonatais – Revisão sistemática. Revista Cuidarte. 2020; 11(2): e1211. http://dx.doi.org/10.15649/cuidarte.1211

Author Biographies

Mara Cristina Ribeiro Furlan, Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul, Brasil.

Sonia Regina Jurado, Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Possui graduação em Ciências Biológicas pela Universidade do Estado do Rio de Janeiro (1995), mestrado em Morfologia pela Universidade do Estado do Rio de Janeiro (1998), doutorado em Fisiopatologia em Clínica Médica pela Universidade Estadual Paulista Júlio de Mesquita Filho (2005) e pós-doutorado em Saúde Pública (2007). Atualmente é tutora do Programa de Educação Tutorial (PET) Enfermagem da Universidade Federal de Mato Grosso do Sul (UFMS), Professora Associada II da UFMS. Possui 20 anos de docência universitária. Tem experiência na área de Medicina, Enfermagem e Biologia, desenvolvendo pesquisas em Saúde Coletiva.

Catchia Hermes Uliana, Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul, Brasil.

Maria Eduarda Pascoaloto Silva , Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul, Brasil.

Letícia Akie Nagata, Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul, Brasil.

Anna Clara Freitas Maia, Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul

Universidade Federal de Mato Grosso do Sul (UFMS), Três Lagoas, Mato Grosso do Sul, Brasil.

References

Hui DS. Epidemic and emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). Clin Chest Med. 2017; 38(1): 71-86. https://doi.org/10.1016/j.ccm.2016.11.007

Li T. Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0). Emerg Microbes Infec. 2020; 9 (1). https://doi.org/10.1080/22221751.2020.1735265

Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020. https://doi.org/10.1016/j.ajogmf.2020.100107

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020; 395: 809-15. https://doi.org/10.1016/S0140-6736(20)30360-3

Mardani M, Pourkaveh B. A Controversial Debate: Vertical Transmission of COVID-19 in Pregnancy. Arch Clin Infect Dis. 2020; 15(1): e102286. https://doi.org/10.5812/archcid.102286

Centers for Disease Control and Prevention. Frequently asked questions and answers: Coronavirus disease 2019 (COVID-19) and pregnancy. CDCP; 2020. https://www.cdc.gov/coronavirus/2019-ncov/faq.html

Qiao Y, Wang J, Li J, Wang J. Effects of depressive and anxiety symptoms during pregnancy on pregnant, obstetric and neonatal outcomes: a follow-up study. J Obstet Gynaecol. 2012; 32(3): 237-40. https://doi.org/10.3109/01443615.2011.647736

Alder J, Fink N, Bitzer J, Hosli I, Holzgreve W. Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern-Fetal Neo M. 2007; 20(3): 189-209. https://doi.org/10.1080/14767050701209560

Fakari RF, Simbar M. Coronavirus Pandemic and Worries during Pregnancy; a Letter to Editor. Arch Acad Emerg Med. 2020; 8(1): e21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075675/pdf/aaem-8-e21.pdf

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020; 395(10224): 565-74. https://doi.org/10.1016/S0140-6736(20)30251-8

Schwartz DA, Graham AL. Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections. Viruses. 2020; 12 (2): 194-210. https://doi.org/10.3390/v12020194

Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Latino-Am Enfermagem. 2007; 15(3): 508-11. https://doi.org/10.1590/S0104-11692007000300023

Moher D, Liberati A, Tetzlaff J, Altman DG. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiol Serv Saúde. 2015; 24(2): 335-42. https://doi.org/10.5123/S1679-49742015000200017

Chen R, Zhang Y, Huang L, Cheng B, Xia Z, Meng Q. Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Can J Anesth. 2020. https://doi.org/10.1007/s12630-020-01630-7

Chen Y, Peng H, Wang L, Zhao Y, Zeng L, Gao H, et al. Infants born to mothers with a new coronavirus (COVID-19). Front. Pediatr. 2020; 8: 104. https://doi.org/10.3389/fped.2020.00104

Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy, Journal of Infection (2020), doi: https://doi.org/10.1016/j.jinf.2020.02.028

Li N, Han L, Peng M, Lv Y, Ouyang Y, Lui K, et al. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. medRxiv. 2020. https://doi.org/10.1101/2020.03.10.20033605

Wang X, Zhou Z, Zhang J, Zhu F, Tang Y, Shen X. A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa200

Chen S, Liao E, Cao Y, Sun G, Shao Y. Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 2020. https://doi.org/10.1002/jmv.25789

Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China. Emerg Infect Dis. 2020; 26(6). https://doi.org/10.3201/eid2606.200287

Word Health Organization. Coronavirus disease 2019 (Covid-19) situation report 46. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_2

Liu H, Lui F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children, J Infect. 2020. https://doi.org/10.1016/j.jinf.2020.03.007

Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: A Preliminary analysis. AJR. 2020; 215: 1-6. https://doi.org/10.1016/j.jinf.2020.03.007

Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G,et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020; 9(1): 51-60. https://doi.org/10.21037/tp.2020.02.06

Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet.2020; 20: 559-64 https://doi.org/10.1016/S1473-3099(20)30176-6

Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv. 2020. https://doi.org/10.1101/2020.01.30.927806

Zambrano LI, Fuentes-Barahona IC, Bejarano-Torres DA, Bustillo C, Gonzalez G, Vallecillo-Chinchilla G, et al. A Pregnant Woman with COVID-19 in Central America. Travel Med Infect Dis. 2020. https://doi.org/10.1016/j.tmaid.2020.101639

Lam CM, Wong SF, Leung TN, Chow KM, Yu WC, Wong TY, et al. A case-controlled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome. BJOG. 2004; 111 (8): 771-74. https://doi.org/10.1111/j.1471-0528.2004.00199.x

Wong SF, Chow KM, Leung TN, Lai ST, Yan WW, Tan PYH, et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol. 2004; 191 (1): 292-97. https://doi.org/10.1016/j.ajog.2003.11.019

Shek CC, Ng PC, Fung GPG, Cheng FWT, Chan PKS, Peirirs MJS, et al. Infants born to mothers with severe acute respiratory syndrome. Pediatrics. 2003; 112(4): e254 https://doi.org/10.1542/peds.112.4.e254

Stockman LA, Lowther SA, Coy K, Saw J, Parashar UD. SARS during Pregnancy, United States. Emerg Infect Dis. 2004;10(9):1689-690. https://doi.org/10.3201/eid1009.040244

Dong Y, Mo X, Hu Y, Tong S. Epidemiological and transmission patterns of pregnant women with 2019 coronavirus disease in China. Lancet. 2020. https://doi.org/10.2139/ssrn.3551330

Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know. Am J Obstet Gynecol. 2020. https://doi.org/10.1016/j.ajog.2020.02.017

Robertson CA, Lowther SA, Births T, Tan C, Sorhage F, Stockman L, et al. SARS and pregnancy: A Case report. Emerg Infect Dis. 2004; 10(2): 345-48. https://doi.org/10.3201/eid1002.030736

Liu W, Wang Q, Zhang Q, Chen L, Chen J, Zhang B, et al. Coronavirus Disease 2019 (COVID-19) During Pregnancy: A Case Series. Preprints 2020, 2020020373 https://www.preprints.org/manuscript/202002.0373/v1

Yue L, Han L, Li Q, Zhong M, Wang J, Wan Z, et al. Anaesthesia and infection control in cesarean section of pregnant women with coronavirus disease 2019 (COVID-19). medRxiv. 2020. https://doi.org/10.1101/2020.03.23.20040394

Fan C, Lei D, Fang C, Li C, Wang M, Liu Y, et al. Perinatal Transmission of COVID-19 associated SARS-CoV-2: Should we worry? Clini Infect Dis, 2020. https://doi.org/10.1093/cid/ciaa226

Lee DH, Lee J, Kim E, Woo K, Park HY, An J. Emergency cesarean section performed in a patient with confirmed severe acute respiratory syndrome Coronavirus-2: A case report. Korean J Anesthesiol. 2020. https://doi.org/10.4097/kja.20116

Khan, S., Peng, L., Siddique, R., Nabi, G., Nawsherwan, Xue, M., . . . Han, G. (2020). Impact of COVID-19 infection on pregnancy outcomes and the risk of maternal-to-neonatal intrapartum transmission of COVID-19 during natural birth. Infection Control & Hospital Epidemiology, 1-3. https://doi.org/10.1017/ice.2020.84

Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. https://doi.org/10.1001/jamapediatrics.2020.0878

Nie R, Wang S, Yang Q, Fan C, Liu Y, He W, et al. Clinical features and the maternal and neonatal outcomes of pregnant women with coronavirus disease 2019. medRxiv. 2020. https://doi.org/10.1101/2020.03.22.20041061

Zeng H, Xu C, Fan J, Thang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA. 2020. https://doi.org/10.1001/jama.2020.4861

Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020. https://doi.org/10.1001/jama.2020.4621

Kochhar DM, Penner JD, Knudsen TB. Embryotoxic, teratogenic, and metabolic effects of ribavirin in mice. Toxicol Appl Pharmacol. 1980; 52(1): 99-112. https://doi.org/10.1016/0041-008X(80)90252-5

Published

2020-05-13

How to Cite

1.
Furlan MCR, Jurado SR, Uliana CH, Silva MEP, Nagata LA, Maia ACF. A Systematic Review of Pregnancy and Coronavirus Infection: Maternal, Fetal and Neonatal Outcomes. Revista Cuidarte [Internet]. 2020 May 13 [cited 2024 Nov. 22];11(2). Available from: https://revistas.udes.edu.co/cuidarte/article/view/1211

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