Mineral and bone disorder: underestimated prevalence in the early stages of chronic kidney disease

Authors

DOI:

https://doi.org/10.15649/cuidarte.2266

Keywords:

Chronic Kidney Disease-Mineral and Bone Disorder, Renal Insufficiency, Chronic, Kidney Failure, Chronic, Hyperparathyroidism, Secondary

Abstract

Introduction: mineral and bone disorder (BMD) is a serious complication of chronic kidney disease (CKD) that increases risks for death from cardiovascular causes and impairs quality of life of affected patients. Objetive: to evaluate the prevalence of BMD in patients with CKD and the association between estimated Glomerular Filtration Rate (eGFR) and BMD indicators (calcium, phosphorus and PTH) in non-dialysis patients. Materials and Methods:sectional study of a two-year cohort of chronic renal adults and elderly patients on conservative treatment. BMD was identified by serum values of: PTH (> 150 pg/mL) and/or hypocalcemia (Ca < 8.8mg/dl) and/or hyperphosphatemia (P > 4.6 mg/dl). The statistical analysis used: Poisson regression; Student's T, Mann Whitney and Pearson and Spearman correlations with 5% significance level. Results:BMD prevalence was 54.6% (n=41) (95% CI: 43.45 - 65.43), more frequent in women, literate, elderly, non-drinkers, non-smokers, sedentary and white skin color. Correlations between P and PTH with GFRe were significant, inverse, moderate strength (p= <0.005 and p = 0.003; correlation coefficients = - 0.312 and - 0.379 respectively). Discussion: the findings of this study highlighted gaps in the monitoring of BMD-DRC by primary care, requiring a review of clinical practices. Conclusion: robust prevalence of BMD in the early stages of CKD was identified, in addition to correlations between increased phosphorus and PTH levels and worsening kidney function.

How to cite this article: Quadros, Karla Amaral Nogueira; Morais, Flávio Augusto de; Vasconcelos, Francisco Edson Coelho de; Watanabe, Yoshimi José Ávila; Bessa, Allan de Morais; Silva, Fernanda Marcelino de Rezende e; Guedes, João Victor Marques; Belo, Vinicius Silva; Cardoso, Clareci Silva; Otoni, Alba. Distúrbio mineral e ósseo: prevalência subestimada nos estágios iniciais da doença renal crónica. Revista Cuidarte. 2022;13(3):e2266. http://dx.doi.org/10.15649/cuidarte.2266     

Author Biographies

Karla Amaral Nogueira Quadros, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

Flávio Augusto de Morais, Secretaria Municipal de Saúde de Divinópolis/MG

Secretaria Municipal de Saúde de Divinópolis/MG, Divinópolis/MG/Brasil.

Francisco Edson Coelho de Vasconcelos, Complexo Hospitalar São João de Deus de Divinópolis/MG

Complexo Hospitalar São João de Deus de Divinópolis/MG, Divinópolis/MG/Brasil.

Yoshimi José Ávila Watanabe, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

Allan de Morais Bessa, Universidade do Estado de Minas Gerais

Universidade do Estado de Minas Gerais (UEMG) unidade de Divinópolis/MG, Divinópolis/MG/Brasil

Fernanda Marcelino de Rezende e Silva, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

João Victor Marques Guedes, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

Vinícius Silva Belo, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

Clareci Silva Cardoso, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil. 

Alba Otoni, Universidade Federal de São João Del Rei

Universidade Federal de São João Del Rei (UFSJ) campus Divinópolis/MG, Divinópolis/MG/Brasil.

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Published

2022-10-10

How to Cite

1.
Quadros KAN, Morais FA de, Vasconcelos FEC de, Watanabe YJ Ávila, Bessa A de M, Silva FM de R e, et al. Mineral and bone disorder: underestimated prevalence in the early stages of chronic kidney disease. Revista Cuidarte [Internet]. 2022 Oct. 10 [cited 2024 Sep. 19];13(3). Available from: https://revistas.udes.edu.co/cuidarte/article/view/2266

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